Dysprosium represents one of the critical rare earth elements/metals that will be in shortage in the near future. Dysprosium, having remarkable chemical and physical properties, is important for sustainable technologies, and there are no replacements for this rare earth metal currently. This shortage is compounded by the increase of dysprosium levels in the environment, influenced by mining and anthropogenic waste. This present study deals with the application of chemometrics methods to model the process parameters for the removal of low concentrations of dysprosium using a microalga as a biosorbent. Percentage removal of dysprosium was dependent on sample conditions. Chemometrics methods proved to be reliable in predicting and modeling bioremoval of dysprosium. These findings suggest that the microalga can be used for the bioremoval and recycling of dysprosium with different rates dependent on the conditions it is applied in.